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3 Results 3.1 Study selection PRISMA 2020 flow diagram for new systematic reviews (see Figure 1 ) indicates the included searches of databases and registers only

As the concentration of liver BAs increases due to intestinal reabsorption, intestinal and liver FXR work together to establish a dynamic balance in BAs by reducing bile acid synthesis and promoting bile acid excretion [90]

This receptor is also expressed, and hence can be studied, in vitro , by the human enteroendocrine cell model NCI-H716 or by the murine GLUTag cell line (320)

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